Publications : SFB/TRR 167

Sankowski R, Strohl JJ, Huerta TS, Nasiri E, Mazzarello AN, D’Abramo C, Cheng KF, Staszewski O, Prinz M, Huerta PT, and Al-Abed Y: Endogenous retroviruses are associated with hippocampus-based memory impairment. PNAS 116 (51) 25982-25990; doi.org/10.1073/pnas.182216411 (2019).

R Mathew N, Vinnakota JM, Apostolova P, Erny D, Hamarsheh S, Andrieux G, Kim JS, Hanke K, Goldmann T, Chappell-Maor L, El-Khawanky N, Ihorst G, Schmidt D, Duyster J, Finke J, Blank T, Boerries M, Blazar BR, Jung S, Prinz M, Zeiser R: Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia. J Clin Invest, pii: 130272; doi: 10.1172/JCI130272 (2019).

Geirsdottir L, David E, Keren-Shaul H, Weiner A, Bohlen SC, Neuber J, Balic A, Giladi A, Sheban F, Dutertre CA, Pfeifle C, Peri F, Raffo-Romero A, Vizioli J, Matiasek K, Scheiwe C, Meckel S, Mätz-Rensing K, van der Meer F, Thormodsson FR, Stadelmann C, Zilkha N, Kimchi T, Ginhoux F, Ulitsky I, Erny D, Amit I, Prinz M: Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program. Cell 179 (7), 1609-1622.e16; doi: 10.1016/j.cell.2019.11.010 (2019).

Buonfiglioli A, Efe IE, Guneykaya D, Ivanov A, Huang Y, Orlowski E, Krüger C, Deisz RA, Markovic D, Flüh C, Newman AG, Schneider UC, Beule D, Wolf SA, Dzaye O, Gutmann DH, Semtner M, Kettenmann H*, Lehnardt S*: let-7 microRNAs regulate microglial function and suppress glioma growth through Toll-like receptor 7. Cell Rep 29(11):3460-3471 (2019). *Equal contribition.

Ziegler JF, Böttcher C, Letizia M, Yerinde C, Wu H, Freise I, Rodriguez-Sillke Y, Stoyanova AK, Kreis ME, Asbach P, Kunkel D, Priller J, Anagnostopoulos I, Kühl AA, Miehle K, Stumvoll M, Tran F, Fredrich B, Forster M, Franke A, Bojarski C, Glauben R, Löscher BS, Siegmund B, Weidinger C: Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease. Nat Commun 10, 5629; doi.org/10.1038/s41467-019-13559-7 (2019).

Ben-Yehuda H, Matcovitch-Natan O, Kertser A, Spinrad A, Prinz M, Amit I and Schwartz M: Maternal Type-I interferon signaling adversely affects the microglia and the behavior of the offspring accompanied by increased sensitivity to stress. Mol Psychiatry; doi: 10.1038/s41380-019-0604-0 (2019).

Chappell-Maor L, Kolesnikov M, Kim JS, Shemer A, Haimon Z, Grozovski J, Boura-Halfon S, Masuda T, Prinz M and Jung S: Comparative analysis of CreER transgenic mice for the study of brain macrophages – a case study. Eur J Immunol; doi: 10.1002/eji.201948342 (2019).

Sankowski R, BöttcherC, Masuda T, Geirsdottir L, Sagar, Sindram E, Seredenina T, Muhs A, Scheiwe C, Shah MJ, Heiland DH, Schnell O, Grün D, Priller J, Prinz M: Mapping microglia states in the human brain through the integration of high-dimensional techniques. Nat Neurosci 22, 2098-2110, doi: 10.1038/s41593-019-0532-y (2019).

Dokalis N, Prinz M: Resolution of neuroinflammation: mechanisms and potential therapeutic option. Semin Immunopathol 41(6), 699-709; doi: 10.1007/s00281-019-00764-1 (2019).

, , , , , and Macrophages are a potent source of streptococcus-induced interferon-β. J Immunol; doi: https://doi.org/10.4049/jimmunol.1900542 (2019).

, Thomas OS, , Unger S, , , Gao Z, , Cywes-Bentley C, Oyardi O, , , Pabst O, , Duyster J, , Blaser MJ, , , Häcker G, and Immunization against poly-N-acetylglucosamine reduces neutrophil activation and GVHD while sparing microbial diversity. Proc Natl Acad Sci U S A 116(41), 20700-20706 (2019).

Prinz M, Jung S, Priller J: Microglia Biology: One Century of Evolving Concepts. Cell 179(2), 292-311; doi: 10.1016/j.cell.2019.08.053 (2019).

O’Connor T, Zhou X, Kosla J, Adili A, Garcia Beccaria M, Kotsiliti E, Pfister D, Johlke AL, Sinha A, Sankowski R, Schick M, Lewis R, Dokalis N, Seubert B, Höchst B, Inverso D, Heide D, Zhang W, Weihrich P, Manske K, Wohlleber D, Anton M9, Hoellein A, Seleznik G, Bremer J, Bleul S, Augustin HG, Scherer F, Koedel U, Weber A, Protzer U, Förster R, Wirth T, Aguzzi A, Meissner F, Prinz M, Baumann B, Höpken UE, Knolle PA, von Baumgarten L, Keller U, Heikenwalder M: Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention. Cancer Cell 36(3), 250-267.e9; doi: 10.1016/j.ccell.2019.08.001 (2019).

Kierdorf K, Prinz M: Microglia: Same same, but different. J Exp Med 216(10), 2223-2225; doi: 10.1084/jem.20191535 (2019).

Kierdorf K, Masuda T, Jordão MJC, Prinz M: Macrophages at CNS interfaces: ontogeny and function in health and disease. Nat Rev Neurosci 20(9):547-562; doi: 10.1038/s41583-019-0201-x (2019).

Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O’Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M: Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer. Nat Med 25(4), 641-655; doi: 10.1038/s41591-019-0379-5 (2019).

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