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Mercator Fellow

Salk Institute for Biological Studies
La Jolla

Fred H. Gage from the Salk Institute for Biological Studies in La Jolla has agreed to become a Mercator fellow of the CRC/TRR167. He is among the most highly cited neuroscientists worldwide (>250,000 citations, h-index 244) and worldrenowned for his discovery of adult neurogenesis in the human brain. More recently, he used human induced pluripotent stem cells (iPSCs) to study the pathogenesis of neuropsychiatric disorders. His expertise will be invaluable to all projects of the CRC/TRR167 that employ iPSCs and organoids to investigate human microglia and CAMs, in particular subprojects A11N (Schäfer/Priller), A07 (Erny/Blank), B03 (Lehnardt/Vincendeau) and B12 (Meisel/Safaiyan). Of particular relevance to the investigators of the CRC/TRR167 is his recent development with Simon Schäfer (A11N) of a chimeric mouse model to study functionally mature human microglia in vivo that operate within a vascularized human brain organoid. This model will allow for unprecedented insight into human microglia biology. As a Mercator fellow, Rusty Gage will be affiliated with the TUM.